Selected article for: "activation recruitment and acute disease severity"
Author: Koenig, Lars M.; Boehmer, Daniel F.R.; Metzger, Philipp; Schnurr, Max; Endres, Stefan; Rothenfusser, Simon
Title: Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19
  • Cord-id: rpfp07nv
  • Document date: 2020_7_17
    • ID: rpfp07nv
    Snippet: An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.
    Document: An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.

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