Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains

Chepur, S. V.; Pluzhnikov, N. N.; Chubar, O. V.; Bakulina, L. S.; Litvinenko, I. V.; Makarov, V. A.; Gogolevsky, A. S.; Myasnikov, V. A.; Myasnikova, I. A.; Al-Shehadat, R. I.

The characteristics of the biology of influenza viruses and coronavirus that determine the implementation of the infectious process are presented. With provision for pathogenesis of infection possible effects of serine proteinase inhibitors, heparin, and inhibitors of heparan sulfate receptors in the prevention of cell contamination by viruses are examined. It has been determined that chelators of metals of variable valency and antioxidants should be used for the reduction of replicative activity of viruses and anti-inflammatory therapy. The possibility of a pH-dependent impairment of glycosylation of cellular and viral proteins was traced for chloroquine and its derivatives. The use of low-toxicity drugs as part of adjunct therapy increases the effectiveness of synthetic antiviral drugs and interferons and ensures the safety of baseline therapy.