Author: Ella N Hartenian; Britt A Glaunsinger
Title: Herpesvirus infection reduces Pol II occupancy of host promoters but spares viral promoters Document date: 2019_3_26
ID: i51almnu_9
Snippet: We induced mRNA decay and host transcriptional repression in these cells by expression of 182 MHV68 muSOX or the herpes simplex virus type 1 (HSV-1) endonuclease vhs. Similar to the 183 host promoters Gapdh and Rplp0, Pol II recruitment to both integrated viral promoters was 184 repressed upon infection with MHV68 but not with R443I (Fig 4A and 5B) . The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . h.....
Document: We induced mRNA decay and host transcriptional repression in these cells by expression of 182 MHV68 muSOX or the herpes simplex virus type 1 (HSV-1) endonuclease vhs. Similar to the 183 host promoters Gapdh and Rplp0, Pol II recruitment to both integrated viral promoters was 184 repressed upon infection with MHV68 but not with R443I (Fig 4A and 5B) . The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/585984 doi: bioRxiv preprint
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