Author: Yang, Hung-Chi; Wu, Yi-Hsuan; Yen, Wei-Chen; Liu, Hui-Ya; Hwang, Tsong-Long; Stern, Arnold; Chiu, Daniel Tsun-Yee
Title: The Redox Role of G6PD in Cell Growth, Cell Death, and Cancer Cord-id: rsl79cxo Document date: 2019_9_8
ID: rsl79cxo
Snippet: The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insul
Document: The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox signaling. Insufficient G6PD activity predisposes cells to growth retardation and demise. Severely lacking G6PD impairs embryonic development and delays organismal growth. Altered G6PD activity is associated with pathophysiology, such as autophagy, insulin resistance, infection, inflammation, as well as diabetes and hypertension. Aberrant activation of G6PD leads to enhanced cell proliferation and adaptation in many types of cancers. The present review aims to update the existing knowledge concerning G6PD and emphasizes how G6PD modulates redox signaling and affects cell survival and demise, particularly in diseases such as cancer. Exploiting G6PD as a potential drug target against cancer is also discussed.
Search related documents:
Co phrase search for related documents- aberrant activation and active form: 1
- aberrant activation and acute ali lung injury: 1, 2, 3
- aberrant activation and adaptive response: 1, 2, 3, 4
- aberrant activation and adipose tissue: 1
- aberrant activation and low molecular weight: 1
- aberrant activation and luciferase reporter: 1
- aberrant activation and lung carcinoma: 1
- aberrant activation and lung injury: 1, 2, 3, 4, 5, 6, 7
- aberrant activation and lupus erythematosus: 1
- acc acetyl coa carboxylase and acetyl coa: 1, 2, 3, 4, 5, 6, 7
- acc acetyl coa carboxylase and acetyl coa carboxylase: 1, 2, 3, 4, 5, 6, 7
- acc acetyl coa carboxylase and liver specific: 1
- acetyl coa and acid synthesis: 1, 2, 3, 4
- acetyl coa and liver specific: 1, 2
Co phrase search for related documents, hyperlinks ordered by date