Author: Arlin Stoltzfus; Ryan W. Norris
Title: On the causes of evolutionary transition:transversion bias Document date: 2015_9_28
ID: 4xocqn6o_11
Snippet: However, the same studies typically do not show significant conservativeness of transitions. In the combined data, a transition has a 53 % chance (CI, 50 % to 56 %) of being more fit than a transversion, only slightly above the null expectation of 50 %. We show that this effect is not large compared to that of most biochemical predictors, and is not large enough to explain the several-fold bias toward transition replacements observed in evolution.....
Document: However, the same studies typically do not show significant conservativeness of transitions. In the combined data, a transition has a 53 % chance (CI, 50 % to 56 %) of being more fit than a transversion, only slightly above the null expectation of 50 %. We show that this effect is not large compared to that of most biochemical predictors, and is not large enough to explain the several-fold bias toward transition replacements observed in evolutionary studies. The mutation-bias hypothesis, though not proven, remains an obvious possibility, while the selective hypothesis would seem untenable.
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