Author: Biasin, M.; Strizzi, S.; Bianco, A.; Macchi, A.; Utyro, O.; Pareschi, G.; Loffreda, A.; Cavalleri, A.; Lualdi, M.; Trabattoni, D.; Tacchetti, C.; Mazza, D.; Clerici, M. S.
Title: UV-A and UV-B Can Neutralize SARS-CoV-2 Infectivity Cord-id: s0bni60d Document date: 2021_5_31
ID: s0bni60d
Snippet: We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10-4 times less efficient than UV-C light. Moreover, by qPCR and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients ca
Document: We performed an in-depth analysis of the virucidal effect of discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm) and violet (405 nm) on SARS-CoV-2. By using a highly infectious titer of SARS-CoV-2 we observed that the violet light-dose resulting in a 2-log viral inactivation is only 10-4 times less efficient than UV-C light. Moreover, by qPCR and fluorescence in situ hybridization (FISH) approach we verified that the viral titer typically found in the sputum of COVID-19 patients can be completely inactivated by the long UV-wavelengths corresponding to UV- A and UV-B solar irradiation. The comparison of the UV action spectrum on SARS-CoV-2 to previous results obtained on other pathogens suggests that RNA viruses might be particularly sensitive to long UV wavelengths. Our data extend previous results showing that SARS-CoV-2 is highly susceptible to UV light and offer an explanation to the reduced incidence of SARS-CoV-2 infection seen in the summer season.
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