Selected article for: "histocompatibility complex and major histocompatibility complex"
Author: Katie M. Campbell; Gabriela Steiner; Daniel K. Wells; Antoni Ribas; Anusha Kalbasi
Title: Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles
  • Document date: 2020_4_1
    • ID: bj454swk_3
    Snippet: The heterogeneity in CD8 T cell responses to SARS-CoV-2 may in part be related to the capacity to recognize the viral antigens in the context of class I major histocompatibility complex (MHC) proteins. Indeed, genetic susceptibilities to viral infection have been tied to human leukocyte antigen (HLA) haplotypes (5) . Meanwhile, functional differences in antigen-specific CD8 T cell responses in symptomatic and asymptomatic patients may also contri.....
    Document: The heterogeneity in CD8 T cell responses to SARS-CoV-2 may in part be related to the capacity to recognize the viral antigens in the context of class I major histocompatibility complex (MHC) proteins. Indeed, genetic susceptibilities to viral infection have been tied to human leukocyte antigen (HLA) haplotypes (5) . Meanwhile, functional differences in antigen-specific CD8 T cell responses in symptomatic and asymptomatic patients may also contribute to the biology of at-risk populations. Together, this knowledge may aid in designing and monitoring the impact of antiviral vaccines.

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