Optimize Clinical Laboratory Diagnosis of COVID-19 from Suspect Cases by Likelihood Ratio of SARS-CoV-2 IgM and IgG antibody

Feng Yangchun

However, the type of antibody test specimen is blood, which is relatively easy to obtain and the infection risk of medical personnel is relatively low. Secondly, according to the quality of detection results, nucleic acid detection is restricted by the quality of sample materials and the extraction quality of nucleic acid, and there is a serious undetected phenomenon. Different sample types have different detection rates, Sucha as bronchoalveolar lavage fluid specimens showed the highest positive rates (93%), sputum (72%), nasal swabs (63%), fibrobronchoscope brush biopsy ( 46%), pharyngeal swabs (32%), feces (29%), and blood (1%) [9] . So continuous nucleic acid detection for several times for some suspected patients is very necessary and can effectively avoid false negative result. For antibody detection, except for some immunocompromised patients, which cannot produce antibodies effectively, antibodies should be present in most infected persons [10] . Antibody detection is mainly limited by the sensitivity and related performance of the kit. In addition, there will be the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.