Author: Han Suh Kang; Katelyn McNair; Daniel A. Cuevas; Barbara A. Bailey; Anca M. Segall; Robert A. Edwards
Title: Prophage genomics reveals patterns in phage genome organization and replication Document date: 2017_3_7
ID: 0abutzb3_38
Snippet: We explored the hypothesis that the tRNA genes compensate for codon bias between the host and the phage. For a tRNA gene found in a prophage, the anticodon was converted to the genomic DNA codon it's associated with. This codon's modal usage was calculated for the prophage's genome, as well as for the host's genome without the prophage sequence. The codon's modal usage in the phage and host was compared using the χ 2 -test. We found that 41.3% o.....
Document: We explored the hypothesis that the tRNA genes compensate for codon bias between the host and the phage. For a tRNA gene found in a prophage, the anticodon was converted to the genomic DNA codon it's associated with. This codon's modal usage was calculated for the prophage's genome, as well as for the host's genome without the prophage sequence. The codon's modal usage in the phage and host was compared using the χ 2 -test. We found that 41.3% of the codons associated with the tRNA found in a prophage had statistically higher modal usage in the phage than in the host (Fig. 6) .
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