Selected article for: "different genetic trait and genetic trait"
Author: Dipender Gill; Marios Arvanitis; Paul Carter; Ana I Hernandez Cordero; Brian Jo; Ville Karhunen; Susanna C Larsson; Xuan Li; Sam M Lockhart; Amy M Mason; Evanthia Pashos; Ashis Saha; Vanessa Tan; Verena Zuber; Yohan Bosse; Sarah Fahle; Ke Hao; Tao Jiang; Philippe Joubert; Alan C Lunt; Willem hendrik Ouwehand; David J Roberts; Wim Timens; Maarten van den Berge; Nicholas A Watkins; Alexis Battle; Adam S Butterworth; John Danesh; Barbara E Engelhard; James E Peters; Don Sin; Stephen Burgess
Title: ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study
  • Document date: 2020_4_14
    • ID: 1kkpx108_27
    Snippet: For all other Mendelian randomization analyses, estimates were obtained from the inverse-variance weighted method under a random-effects model (45) . For the polygenic analyses based on the ACE gene locus, we accounted for correlation between variants (46) . Heterogeneity between Mendelian randomization estimates from different genetic variants for the same exposure trait was expressed using the I 2 statistic (47) . For any identified association.....
    Document: For all other Mendelian randomization analyses, estimates were obtained from the inverse-variance weighted method under a random-effects model (45) . For the polygenic analyses based on the ACE gene locus, we accounted for correlation between variants (46) . Heterogeneity between Mendelian randomization estimates from different genetic variants for the same exposure trait was expressed using the I 2 statistic (47) . For any identified associations at p< 0.05, the weighted median (48), MR-Egger (49) and contamination-mixture methods (50) , which are more robust to the inclusion of pleiotropic variants, were performed as sensitivity analyses.

    Search related documents:
    Co phrase search for related documents
    • contamination mixture and inverse variance: 1
    • contamination mixture and mendelian randomization: 1
    • contamination mixture method and inverse variance: 1
    • contamination mixture method and mendelian randomization: 1
    • different genetic variant and genetic variant: 1, 2, 3
    • gene locus and identified association: 1, 2, 3, 4, 5, 6, 7, 8
    • gene locus and mendelian randomization: 1
    • genetic variant and identified association: 1, 2, 3, 4, 5, 6
    • identified association and inverse variance: 1
    • identified association and mendelian randomization: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • identified association and mendelian randomization analysis: 1
    • inverse variance and mendelian randomization: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • inverse variance and mendelian randomization analysis: 1, 2, 3, 4, 5
    • inverse variance and mendelian randomization estimate: 1
    • inverse variance obtain and mendelian randomization: 1, 2
    • mendelian randomization analysis and polygenic analysis: 1
    • mendelian randomization and polygenic analysis: 1, 2