Author: Zehua Zeng; Zhi Luo; Hongwu Du
Title: Predictions for the binding domain and potential new drug targets of 2019-nCoV Document date: 2020_3_2
ID: fvig79k3_5
Snippet: Iterative Threading Assembly Refinement (I-TASSER) is a layered method for protein structure and function prediction 3 .It firstly identifies the structural template from the PDB through the local meta-threaded method (LOMETS), and then constructs the full-length atomic model through the fragment assembly simulation based on the iterative template. Next, the 3D model is re-woven into the thread through BioLiP, the protein function database, to yi.....
Document: Iterative Threading Assembly Refinement (I-TASSER) is a layered method for protein structure and function prediction 3 .It firstly identifies the structural template from the PDB through the local meta-threaded method (LOMETS), and then constructs the full-length atomic model through the fragment assembly simulation based on the iterative template. Next, the 3D model is re-woven into the thread through BioLiP, the protein function database, to yield a functional insight into the target. In the recent protein structure predictions for CASP7, CASP8, CASP9, CASP10, CASP11, CASP12 and CASP13, I-TASSER remains one of the best method for the automated protein structure prediction 3 .
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