Current diagnostic tools for coronaviruses–From laboratory diagnosis to POC diagnosis for COVID‐19

Wang, Yung‐Chih; Lee, Yi‐Tzu; Yang, Ting; Sun, Jun‐Ren; Shen, Ching‐Fen; Cheng, Chao‐Min

The Coronavirus‐2019 (COVID‐19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID‐19 from other acute respiratory tract infections via clinical symptoms because those who are infected display a wide range of symptoms. An effective, point‐of‐care (POC) diagnostic tool could mitigate healthcare system strain, protect healthcare professionals, and support quarantine efforts. We believe that a POC tool can be developed that would be rapid, easy to use, and inexpensive. It could be used in the home, in resource‐limited areas, and even in clinical settings. In this article, we summarize the current state of POC tools and propose an all‐in‐one, highly sensitive POC assay that integrates antibody detection, protein detection, and serum cytokine detection to diagnose COVID‐19 infection. We believe this article will provide insight into the current state of POC diagnostics for COVID‐19, and promote additional research and tool development that could be exceptionally impactful.