Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_63
Snippet: Conversely, we cannot establish if the slightly higher RMSD observed between the native ACE2 However, also admitting that ACE1 inhibitors at the employed dosage would target ACE2, with the same efficiency observed versus ACE1, the presence of those inhibitors in ACE2 binding cavity should not be able to induce an important conformational change in ACE2, which might favour a greater affinity of ACE2 versus SARS-CoV-2 spike RBD......
Document: Conversely, we cannot establish if the slightly higher RMSD observed between the native ACE2 However, also admitting that ACE1 inhibitors at the employed dosage would target ACE2, with the same efficiency observed versus ACE1, the presence of those inhibitors in ACE2 binding cavity should not be able to induce an important conformational change in ACE2, which might favour a greater affinity of ACE2 versus SARS-CoV-2 spike RBD.
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