Author: Ting Gao; Mingdong Hu; Xiaopeng Zhang; Hongzhen Li; Lin Zhu; Hainan Liu; Qincai Dong; Zhang Zhang; Zhongyi Wang; Yong Hu; Yangbo Fu; Yanwen Jin; Kaitong Li; Songtao Zhao; Yongjiu Xiao; Shuping Luo; Lufeng Li; Lingfang Zhao; Junli Liu; Huailong Zhao; Yue Liu; Weihong Yang; Jing Peng; Xiaoyu Chen; Ping Li; Yaoning Liu; Yonghong Xie; Jibo Song; Lu Zhang; Qingjun Ma; Xiuwu Bian; Wei Chen; Xuan Liu; Qing Mao; Cheng Cao
Title: Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation Document date: 2020_3_30
ID: dxs8ggyh_21
Snippet: In the past 17 years, successively emerged SARS-CoV, MERS-CoV and SARS-CoV-2 broke through the species barrier and brought new infectious diseases and social panic to human. All these highly pathogenic coronavirus cause acute lung injury and acute respiratory distress syndrome (ARDS), therefore resulting in an increased severity and lethality. Patients infected with the virus may develop to atypical pneumonia resulting from severe immune injury. .....
Document: In the past 17 years, successively emerged SARS-CoV, MERS-CoV and SARS-CoV-2 broke through the species barrier and brought new infectious diseases and social panic to human. All these highly pathogenic coronavirus cause acute lung injury and acute respiratory distress syndrome (ARDS), therefore resulting in an increased severity and lethality. Patients infected with the virus may develop to atypical pneumonia resulting from severe immune injury. The 15 excessive human immune responses that were characterized by the extensive release of proinflammatory cytokines and chemokines, called a "cytokine storm" (5) , is thought to be the major initiator of the sever pneumonia caused by high pathogenic coronavirus, including the latest SARS-CoV-2 (4). Although immunopathogenesis has been partially implicated in SARS or MERS, the mechanism responsible for virus-induced hyper-activation of host immune system 20 remains poorly understood.
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