Author: Bedin, Anne-Sophie; Makinson, Alain; Picot, Marie-Christine; Mennechet, Franck; Malergue, Fabrice; Pisoni, Amandine; Nyiramigisha, Esperance; Montagnier, Lise; Bollore, Karine; Debiesse, Segolene; Morquin, David; Bourgoin, Penelope; Veyrenche, Nicolas; Renault, Constance; Foulongne, Vincent; Caroline, Bret; Arnaud, Bourdin; Moing, Vincent Le; Perre, Philippe Van de; TUAILLON, Edouard
Title: Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19 Cord-id: sn6sus8o Document date: 2020_6_29
ID: sn6sus8o
Snippet: We assessed the expression of the cell adhesion molecule Sialoadhesin (CD169), a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, compared to three out of 21 (14.3%) patients for whom the diagnosis of COVID-19 was finally ruled out. mCD169 was associated with the plasma interferon alpha l
Document: We assessed the expression of the cell adhesion molecule Sialoadhesin (CD169), a type I interferon-inducible receptor, on monocytes (mCD169) in 53 adult patients admitted to the hospital during the COVID-19 outbreak for a suspicion of SARS-CoV-2 infection. mCD169 was strongly overexpressed in 30 out of 32 (93.7%) confirmed COVID-19 cases, compared to three out of 21 (14.3%) patients for whom the diagnosis of COVID-19 was finally ruled out. mCD169 was associated with the plasma interferon alpha level and thrombocytopenia. mCD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.
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