Selected article for: "host translational shut and MHV infection"
Author: Georgia M. Cook; Katherine Brown; Krzysztof Franaszek; Nathan A. Moore; Stuart G. Siddell; Ian Brierley; Andrew E. Firth; Nerea Irigoyen
Title: Probing the unfolded protein response to mouse hepatitis coronavirus infection through RNA sequencing and ribosome profiling
  • Document date: 2018_3_31
    • ID: hxugy10i_3
    Snippet: CoVs induce host translational shut-off [24-29] although the mechanisms are not completely 152 understood. We reasoned that some host genes may be resistant to virus-induced shut-off and that 153 identifying such genes might give new insights into the shut-off mechanism(s). To evaluate 154 differences at the level of translation as a result of MHV infection, we calculated relative translation 155 efficiencies (TE) -defined herein as the ratio of .....
    Document: CoVs induce host translational shut-off [24-29] although the mechanisms are not completely 152 understood. We reasoned that some host genes may be resistant to virus-induced shut-off and that 153 identifying such genes might give new insights into the shut-off mechanism(s). To evaluate 154 differences at the level of translation as a result of MHV infection, we calculated relative translation 155 efficiencies (TE) -defined herein as the ratio of ribosome-protected-fragment (RPF) and total RNA 156 density in the CDS of a given gene -at 5 h p.i. using Xtail [30] , applying the same fold change and 157 p-value thresholds as for the transcription analysis. As shown in Fig 2A, Supplementary Fig 2) . Comparison of RPF distribution with 179

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