Selected article for: "colorectal cancer and normal control"
Author: Haoyan Chen; Baoqin Xuan; Yuqing Yan; Xiaoqiang Zhu; Chaoqin Shen; Gang Zhao; Linhua Ji; Danhua Xu; Hua Xiong; TaChung Yu; Xiaobo Li; Qiang Liu; Yingxuan Chen; Yun Cui; Jie Hong; Jing-Yuan Fang
Title: Profiling ACE2 expression in colon tissue of healthy adults and colorectal cancer patients by single-cell transcriptome analysis
  • Document date: 2020_2_23
    • ID: 3r0nqzgu_6
    Snippet: Consistently, in GSE81861 dataset, ACE2 is expressed in 10.5%(62/590) of all human colon cells. We also observed that the ACE2 expressed cells were significantly enriched in colorectal tumors when compared with healthy normal tissues (12.5% vs 7.0%, p < 0.05) (Fig.1D-F) . Those results intrigue us to investigated whether ACE2 is also enriched in precancerous lesion of colorectal tumor, such as colorectal adenoma(CRA). We performed single cell RNA.....
    Document: Consistently, in GSE81861 dataset, ACE2 is expressed in 10.5%(62/590) of all human colon cells. We also observed that the ACE2 expressed cells were significantly enriched in colorectal tumors when compared with healthy normal tissues (12.5% vs 7.0%, p < 0.05) (Fig.1D-F) . Those results intrigue us to investigated whether ACE2 is also enriched in precancerous lesion of colorectal tumor, such as colorectal adenoma(CRA). We performed single cell RNA profiling on the tissues from colorectal cancer, colorectal adenoma and healthy normal control from Renji Hospital hospital.

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