Author: Kim, Myung-Ho; Salloum, Shadi; Wang, Jeffrey Y; Wong, Lai Ping; Regan, James; Lefteri, Kristina; Manickas-Hill, Zachary; Gao, Ce; Li, Jonathan Z; Sadreyev, Ruslan I; Yu, Xu G; Chung, Raymond T; Lai Ping, Wong
Title: Type I, II, and III Interferon Signatures Correspond to Coronavirus Disease 2019 Severity. Cord-id: suv9gj0l Document date: 2021_9_1
ID: suv9gj0l
Snippet: We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compromised in intensive care unit patients. Type III IFN responses were induced in the early phase of infect
Document: We analyzed plasma levels of interferons (IFNs) and cytokines, and expression of IFN-stimulated genes in peripheral blood mononuclear cells in patients with coronavirus disease 2019 of varying disease severity. Patients hospitalized with mild disease exhibited transient type I IFN responses, while intensive care unit patients had prolonged type I IFN responses. Type II IFN responses were compromised in intensive care unit patients. Type III IFN responses were induced in the early phase of infection, even in convalescent patients. These results highlight the importance of early type I and III IFN responses in controlling coronavirus disease 2019 progression.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date