Author: Ting Gao; Mingdong Hu; Xiaopeng Zhang; Hongzhen Li; Lin Zhu; Hainan Liu; Qincai Dong; Zhang Zhang; Zhongyi Wang; Yong Hu; Yangbo Fu; Yanwen Jin; Kaitong Li; Songtao Zhao; Yongjiu Xiao; Shuping Luo; Lufeng Li; Lingfang Zhao; Junli Liu; Huailong Zhao; Yue Liu; Weihong Yang; Jing Peng; Xiaoyu Chen; Ping Li; Yaoning Liu; Yonghong Xie; Jibo Song; Lu Zhang; Qingjun Ma; Xiuwu Bian; Wei Chen; Xuan Liu; Qing Mao; Cheng Cao
Title: Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation Document date: 2020_3_30
ID: dxs8ggyh_26
Snippet: Firstly, neutralization of N protein in the serum by antibody effectively alleviated lung injury and reduced the fatality in LPS/Ad-SARS N challenged mice. Coincidentally, SARS patients who produce higher levels of N protein specific but not spike protein specific antibodies 10 tend to recover more rapidly, suggesting that levels of N antibodies correlated with outcome of SARS (37). According to our findings, similar mechanisms may be present in .....
Document: Firstly, neutralization of N protein in the serum by antibody effectively alleviated lung injury and reduced the fatality in LPS/Ad-SARS N challenged mice. Coincidentally, SARS patients who produce higher levels of N protein specific but not spike protein specific antibodies 10 tend to recover more rapidly, suggesting that levels of N antibodies correlated with outcome of SARS (37). According to our findings, similar mechanisms may be present in MERS-CoV or SARS-CoV-2 infection.
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