Profiles of liver function abnormalities in elderly patients with Coronavirus Disease 2019

Yu, Xiaomei; He, Wenbo; Wang, Lang; Bao, Mingwei; Liu, Huafen; Zhou, Jiali; Jiang, Hong

BACKGROUND: The profiles of liver function abnormalities in COVID‐19 patients need to be clarified. METHODS: In this retrospective study, consecutive COVID‐19 patients over 60 years old in Renmin Hospital of Wuhan University from Jan 1 to Feb 6 were included. Data of demographics, clinical characteristics, comorbidities, laboratory tests, medications and outcomes were collected and analyzed. Sequential alterations of serum alanine aminotransferase (ALT) were monitored. RESULTS: 330 patients were included and classified into two groups with normal (n=234) or elevated ALT (n=96). There were fewer females (40.6% vs 54.7%, P=0.020) and more critical cases (30.2% vs. 19.2%, P=0.026) in patients with elevated ALT compared to the normal group. Higher levels of bacterial infection indices (e.g. white blood cell count, neutrophil count, C‐reactive protein and procalcitonin) were observed in the elevated group. Spearman correlation showed that both ALT and AST levels were positively correlated with those indices of bacterial infection. No obvious effects of medications on ALT abnormalities were found. In patients with elevated ALT, most ALT elevations were mild and transient. 59.4% of the patients had ALT concentrations of 41–100 U/L, while only a few patients (5.2%) had high serum ALT concentrations above 300 U/L. ALT elevations occurred at 13 (10–17) days and recovered at 28 (18–35) days from disease onset. For most patients, the elevation of serum ALT levels occurred at 6–20 days after disease onset and reached their peak values within a similar time frame. The recovery of serum ALT levels to normal frequently occurred at 16–20 days or 31–35 days after disease onset. CONCLUSIONS: Liver function abnormalities were observed in 29.1% of the elderly COVID‐19 patients, which were slightly and transient in most cases. Liver function abnormalities in COVID‐19 may be correlated with bacterial infection.