Selected article for: "cell response and NK cell"

Author: Jassem, Jacek; Marek-Trzonkowska, Natalia Maria; Smiatacz, Tomasz; Arcimowicz, Łukasz; Papak, Ines; Jassem, Ewa; Zaucha, Jan Maciej
Title: Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
  • Cord-id: p3ygt90h
  • Document date: 2021_10_10
  • ID: p3ygt90h
    Snippet: We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectivel
    Document: We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vβ2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectively respond to anti-SARS-CoV-2 treatment when NK and antigen-specific Tc cell response is induced.

    Search related documents:
    Co phrase search for related documents
    • adaptive innate and long term infection: 1, 2
    • adaptive innate and lymphocyte count: 1, 2
    • adaptive innate and lymphocyte subset: 1
    • adaptive innate and lymphocytic leukemia: 1, 2
    • adaptive innate and lymphoma patient: 1, 2
    • adaptive innate and mab monoclonal antibody: 1, 2
    • adaptive innate immune system and long term infection: 1
    • adaptive innate immune system and lymphocyte subset: 1
    • lobular pneumonia and lymphoma patient: 1
    • long term control and lymphocyte count: 1
    • long term control and lymphocyte subset: 1
    • long term infection and lymphocytic leukemia: 1
    • long term infection and lymphoma patient: 1
    • lymphocyte count and mab monoclonal antibody: 1