Author: Ben Longdon; Jonathan P Day; Joel M Alves; Sophia CL Smith; Thomas M Houslay; John E McGonigle; Lucia Tagliaferri; Francis M Jiggins
Title: Host shifts result in parallel genetic changes when viruses evolve in closely related species Document date: 2017_11_28
ID: ithoxu6k_3
Snippet: In some instances adaptation to a novel host relies on specific mutations that arise repeatedly 45 whenever a pathogen switches to a given host. For example, in the jump of HIV-1 from chimps to 46 humans, codon 30 of the gag gene has undergone a change that increases virus replication in 47 humans, and this has occurred independently in all three HIV-1 lineages [5, 16] . Similarly, five 48 parallel mutations have been observed in the two independ.....
Document: In some instances adaptation to a novel host relies on specific mutations that arise repeatedly 45 whenever a pathogen switches to a given host. For example, in the jump of HIV-1 from chimps to 46 humans, codon 30 of the gag gene has undergone a change that increases virus replication in 47 humans, and this has occurred independently in all three HIV-1 lineages [5, 16] . Similarly, five 48 parallel mutations have been observed in the two independent epidemics of SARS coronavirus 49 following its jump from palm civets into humans [17] . Similar patterns have been seen in
Search related documents:
Co phrase search for related documents- gag gene and virus replication: 1, 2, 3
- give host and novel host: 1, 2, 3, 4, 5
- give host and virus replication: 1
- independently occur and virus replication: 1
- novel host adaptation and virus replication: 1
- novel host and palm civet: 1
- novel host and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45
- palm civet and virus replication: 1, 2
- parallel mutation and specific mutation: 1
- similar pattern and virus replication: 1, 2, 3, 4
- specific mutation and virus replication: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date