Author: Gharbharan, A.; Jordans, C. C. E.; GeurtsvanKessel, C.; den Hollander, J. G.; Karim, F.; Mollema, F. P. N.; Stalenhoef, J. E.; Dofferhoff, A.; Ludwig, I.; Koster, A.; Hassing, R.-J.; Bos, J. C.; van Pottelberge, G. R.; Vlasveld, I. N.; Ammerlaan, H. S. M.; Segarceanu, E.; Miedema, J.; van der Eerden, M.; Papageorgiou, G.; te Broekhorst, P.; Swaneveld, F. H.; Katsikis, P. D.; Mueller, Y.; Okba, N. M. A.; Koopmans, M. P. G.; Haagmans, B. L.; Rokx, C.; Rijnders, B.
Title: Convalescent Plasma for COVID-19. A randomized clinical trial Cord-id: qgwu9fsk Document date: 2020_7_3
ID: qgwu9fsk
Snippet: Background After recovery from COVID-19, most patients have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an inexpensive and widely available treatment for COVID-19. Methods The Convalescent-plasma-for-COVID (ConCOVID) study was a randomized trial comparing convalescent plasma with standard of care therapy in patients hospitalized for COVID-19 in the Netherlands. Patients were randomized 1:1 and received 300ml of plasma with anti-SARS-CoV-2 neutralizing antibody tit
Document: Background After recovery from COVID-19, most patients have anti-SARS-CoV-2 neutralizing antibodies. Their convalescent plasma could be an inexpensive and widely available treatment for COVID-19. Methods The Convalescent-plasma-for-COVID (ConCOVID) study was a randomized trial comparing convalescent plasma with standard of care therapy in patients hospitalized for COVID-19 in the Netherlands. Patients were randomized 1:1 and received 300ml of plasma with anti-SARS-CoV-2 neutralizing antibody titers of at least 1:80. The primary endpoint was day-60 mortality and key secondary endpoints were hospital stay and WHO 8-point disease severity scale improvement on day 15. Results The trial was halted prematurely after 86 patients were enrolled. Although symptomatic for only 10 days (IQR 6-15) at the time of inclusion, 53 of 66 patients tested had anti-SARS-CoV-2 antibodies at baseline. A SARS-CoV-2 plaque reduction neutralization test showed neutralizing antibodies in 44 of the 56 (79%) patients tested with median titers comparable to the 115 donors (1:160 vs 1:160, p=0.40). These observations caused concerns about the potential benefit of convalescent plasma in the study population and after discussion with the data safety monitoring board, the study was discontinued. No difference in mortality (p=0.95), hospital stay (p=0.68) or day-15 disease severity (p=0.58) was observed between plasma treated patients and patients on standard of care. Conclusion Most COVID-19 patients already have high neutralizing antibody titers at hospital admission. Screening for antibodies and prioritizing convalescent plasma to risk groups with recent symptom onset will be key to identify patients that may benefit from convalescent plasma. Clinicaltrials.gov: NCT04342182
Search related documents:
Co phrase search for related documents- access program and logistic regression: 1, 2, 3, 4, 5
- activity limitation and logistic regression: 1, 2, 3, 4
- adjust logistic regression analysis and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9
- adjust logistic regression and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50
- admission disease onset time and lopinavir ritonavir: 1, 2, 3
- logistic regression and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
Co phrase search for related documents, hyperlinks ordered by date