Author: William T Gibson; Daniel M Evans; Jianghong An; Steven JM Jones
Title: ACE 2 Coding Variants: A Potential X-linked Risk Factor for COVID-19 Disease Document date: 2020_4_14
ID: 05w8tv8x_5
Snippet: We note here that the ACE2 gene is located on the X-chromosome; human males are 77 hemizygous for the gene, expressing only one haplotype from their maternally-derived allele. Females, 78 by contrast, have two X chromosomes and generally express both their paternal and maternal alleles in 79 a mosaic distribution that is determined by early X-inactivation. Since we have prior knowledge that 80 the ACE2 protein is bound directly by the viral S pro.....
Document: We note here that the ACE2 gene is located on the X-chromosome; human males are 77 hemizygous for the gene, expressing only one haplotype from their maternally-derived allele. Females, 78 by contrast, have two X chromosomes and generally express both their paternal and maternal alleles in 79 a mosaic distribution that is determined by early X-inactivation. Since we have prior knowledge that 80 the ACE2 protein is bound directly by the viral S protein, and since prior protein-protein interaction 81 modelling has identified specific amino acid residues within ACE2 that are bound directly by SARS-82
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