Author: Timothy A. Dinh; Ramja Sritharan; F. Donelson Smith; Adam B. Francisco; Rosanna K. Ma; Rodica P. Bunaciu; Matt Kanke; Charles G. Danko; Andrew P. Massa; John D. Scott; Praveen Sethupathy
Title: Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance Document date: 2020_1_18
ID: bf4qpsy7_39
Snippet: In sum, we have used ChRO-seq to map the transcriptional and enhancer landscape of FLC. The genome-scale information provided by ChRO-seq allowed us to identify candidate master transcriptional regulators of FLC and novel candidate FLC oncogenes, demonstrating the power of such genomic approaches. Follow-up functional studies in AML12 cells expressing Dnajb1-Prkaca and a newly derived human FLC cell culture revealed new candidate therapeutic stra.....
Document: In sum, we have used ChRO-seq to map the transcriptional and enhancer landscape of FLC. The genome-scale information provided by ChRO-seq allowed us to identify candidate master transcriptional regulators of FLC and novel candidate FLC oncogenes, demonstrating the power of such genomic approaches. Follow-up functional studies in AML12 cells expressing Dnajb1-Prkaca and a newly derived human FLC cell culture revealed new candidate therapeutic strategies for FLC.
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