Author: Seibert, Felix S.; Toma, Daniela; Bauer, Frederic; Paniskaki, Krystallenia; Anft, Moritz; Rohn, Benjamin J.; Wang, Simon; Racovitan, Diana; Babel, Nina; Westhoff, Timm H.
Title: Detection of SARS-CoV-2 pneumonia: two case reports Cord-id: tni3p1lp Document date: 2020_12_11
ID: tni3p1lp
Snippet: BACKGROUND: Developing therapeutic strategies for a SARS-CoV-2 infection is challenging, but first the correct diagnosis has to be made. Unspecific upper and lower respiratory tract symptoms can be misleading; hence, a nasopharyngeal swab test with a real-time reverse-transcription-polymerase chain reaction is of great importance. However, early viral clearing jeopardizes a sound diagnosis of COVID-19. CASE PRESENTATION: We report on two Caucasian patients who had negative pharyngeal swab tests
Document: BACKGROUND: Developing therapeutic strategies for a SARS-CoV-2 infection is challenging, but first the correct diagnosis has to be made. Unspecific upper and lower respiratory tract symptoms can be misleading; hence, a nasopharyngeal swab test with a real-time reverse-transcription-polymerase chain reaction is of great importance. However, early viral clearing jeopardizes a sound diagnosis of COVID-19. CASE PRESENTATION: We report on two Caucasian patients who had negative pharyngeal swab tests at the onset of SARS-CoV-2 pneumonia. In one patient, the virus was not even detectable in bronchoalveolar lavage despite typical radiomorphologic changes. CONCLUSIONS: Negative PCR findings in both the pharynx and bronchoalveolar lavage do not exclude COVID-19 pneumonia. Computed tomography is a crucial diagnostic prerequisite in this context.
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