Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples Document date: 2020_4_22
ID: 0tdfvlqd_2
Snippet: Unfortunately, the existing antibody detection methods are still far from adequate. The gold nanoparticle based lateral flow assay (e.g., paper-based test strips) is very popular in rapid detection of IgG/IgM antibodies (especially for point-of-care diagnostics) 9-14 . Although fast (5-20 minutes) , it provides only yes/no information and has very limited sensitivities, making this method very easy to generate false positives/negative and impossi.....
Document: Unfortunately, the existing antibody detection methods are still far from adequate. The gold nanoparticle based lateral flow assay (e.g., paper-based test strips) is very popular in rapid detection of IgG/IgM antibodies (especially for point-of-care diagnostics) 9-14 . Although fast (5-20 minutes) , it provides only yes/no information and has very limited sensitivities, making this method very easy to generate false positives/negative and impossible to track the patients' immune response to infection, treatment, and vaccination. Conventional ELISA (enzyme-linked immunosorbent assay), on the other hand, can provide quantitative, accurate, and sensitive results, but it involves complicated and expensive instruments and long assay time (2-3 hours) 5, 15 . In addition, samples need to be sent to centralized labs, which significantly increases the turn-around time.
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