Author: Xiaotian Tan; Cory Lin; Jie Zhang; Maung Kyaw Khaing Oo; Xudong Fan
Title: Rapid and quantitative detection of COVID-19 markers in micro-liter sized samples Document date: 2020_4_22
ID: 0tdfvlqd_25
Snippet: is the first biomarker that we aim to detect. The mechanism of IgG detection is illustrated in Figure 2 (A). First, S1 protein is immobilized on the capillary inner surface through a poly-histidine mediation approach (see Figures S1 and S2(A) for details). Then, S1 specific IgG in the sample (such as serum) is attracted to the surface through immunosorbent reaction. Finally, the HRPconjugated detection antibody is used to visualize the binding .....
Document: is the first biomarker that we aim to detect. The mechanism of IgG detection is illustrated in Figure 2 (A). First, S1 protein is immobilized on the capillary inner surface through a poly-histidine mediation approach (see Figures S1 and S2(A) for details). Then, S1 specific IgG in the sample (such as serum) is attracted to the surface through immunosorbent reaction. Finally, the HRPconjugated detection antibody is used to visualize the binding of the immobilized IgG. To ensure detection specificity, a monoclonal detection antibody that binds specifically to the Fc domain on human IgG was used. According to the protocol in Figure S2 (B), the entire assay was completed in 15 minutes.
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