Selected article for: "eqtl analysis and gene expression"
Author: Dipender Gill; Marios Arvanitis; Paul Carter; Ana I Hernandez Cordero; Brian Jo; Ville Karhunen; Susanna C Larsson; Xuan Li; Sam M Lockhart; Amy M Mason; Evanthia Pashos; Ashis Saha; Vanessa Tan; Verena Zuber; Yohan Bosse; Sarah Fahle; Ke Hao; Tao Jiang; Philippe Joubert; Alan C Lunt; Willem hendrik Ouwehand; David J Roberts; Wim Timens; Maarten van den Berge; Nicholas A Watkins; Alexis Battle; Adam S Butterworth; John Danesh; Barbara E Engelhard; James E Peters; Don Sin; Stephen Burgess
Title: ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study
  • Document date: 2020_4_14
    • ID: 1kkpx108_22
    Snippet: GTEx genetic association estimates were obtained in 515 individuals of predominantly European (85%) ancestry. Whole genome sequencing was performed by the Broad Institute's Genomics Platform and only common variants (minor allele frequency > 0.05) were retained. Genome-wide eQTL analysis was performed for the expression of ACE2 and TMPRSS2 in primary tissue samples taken from the lung. Genetic associations with imputed variants across the autosom.....
    Document: GTEx genetic association estimates were obtained in 515 individuals of predominantly European (85%) ancestry. Whole genome sequencing was performed by the Broad Institute's Genomics Platform and only common variants (minor allele frequency > 0.05) were retained. Genome-wide eQTL analysis was performed for the expression of ACE2 and TMPRSS2 in primary tissue samples taken from the lung. Genetic associations with imputed variants across the autosomal chromosomes were adjusted for five principal components from the genotype data, 60 probabilistic estimation of expression residuals factors (41), sequencing platform (Illumina HiSeq 2000 or HiSeq X), sequencing protocol (polymerase chain reaction-based or free), and sex. For each gene, expression values between samples were normalized using the trimmed means of M-values method in EdgeR (42) . Expression values were normalized across samples using an inverse normal transformation.

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