Tinnitus following COVID-19 vaccination: report of three cases.

Parrino, Daniela; Frosolini, Andrea; Gallo, Chiara; De Siati, Romolo Daniele; Spinato, Giacomo; de Filippis, Cosimo

OBJECTIVE To ensure the safety and quality of vaccines, especially the newest RNA-vaccines against COVID-19, is one of the World Health Organization's current highest priorities. DESIGN Case description. STUDY SAMPLE We report three cases of sudden unilateral tinnitus following BNT162b2 mRNA-vaccine injection, which rapidly resolved in 2 out of 3 cases. RESULTS The mechanism responsible for its development remains unclear. A hypersensitivity reaction with an abnormal autoimmune response or a vasculitic event may be implicated. CONCLUSIONS Large-scale and well-designed studies are needed to improve surveillance of the COVID-19 vaccine and better define possible adverse reactions involving the cochleo-vestibular system and/or immunisation anxiety-related reactions.