Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_16
Snippet: The proposed complete IgG chimeric antibodies were obtained by superimposing the above cited m396 and the resulting engineered FAB portions, in complex with SARS-CoV-1/2 RBD, to the 3D atomic model of a crystallized IgG, available on the PDB (1igt.pdb, (48)) by using SPDBV and PyMOL, according to our validated protocols (29, 30, 49) , that allow to model missing residues, solving clashes and breaks in the backbone......
Document: The proposed complete IgG chimeric antibodies were obtained by superimposing the above cited m396 and the resulting engineered FAB portions, in complex with SARS-CoV-1/2 RBD, to the 3D atomic model of a crystallized IgG, available on the PDB (1igt.pdb, (48)) by using SPDBV and PyMOL, according to our validated protocols (29, 30, 49) , that allow to model missing residues, solving clashes and breaks in the backbone.
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