Author: Chengxin Zhang; Wei Zheng; Xiaoqiang Huang; Eric W. Bell; Xiaogen Zhou; Yang Zhang
Title: Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1 Document date: 2020_2_8
ID: mtv80pjo_5
Snippet: Putting these together, we believe that there is a close evolutionary relation between 2019-nCoV and bat coronavirus RaTG13. The four insertions highlighted by Pradhan et al. in the spike protein are not unique to 2019-nCoV and HIV-1. In fact, they are shared with many other viruses including the bat coronavirus. Yes, the similarities in the sequence-based alignments built on these very short fragments are statistically insignificant, as assessed.....
Document: Putting these together, we believe that there is a close evolutionary relation between 2019-nCoV and bat coronavirus RaTG13. The four insertions highlighted by Pradhan et al. in the spike protein are not unique to 2019-nCoV and HIV-1. In fact, they are shared with many other viruses including the bat coronavirus. Yes, the similarities in the sequence-based alignments built on these very short fragments are statistically insignificant, as assessed by the BLAST E-values. Structurally, these "insertions" are far away from the binding interface of the spike protein with the ACE2 receptor, as shown in Figure 2 , which are also contradictory with the conclusion made by Pradhan et al. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.04.933135 doi: bioRxiv preprint
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