Author: Zhang, Qi-Yu; Yan, Zhi-Bin; Meng, Yue-Ming; Hong, Xiang-Yu; Shao, Gang; Ma, Jun-Jie; Cheng, Xu-Rui; Liu, Jun; Kang, Jian; Fu, Cai-Yun
Title: Antimicrobial peptides: mechanism of action, activity and clinical potential Cord-id: pn1qd6bb Document date: 2021_9_9
ID: pn1qd6bb
Snippet: The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This com
Document: The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00343-2.
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