Evidence from a humanized mouse model of androgenetic alopecia that platelet-rich plasma (PRP) stimulates hair regrowth, hair shaft diameter and vellus-to-terminal hair reconversion in vivo.

Laufer Britva, R; Keren, A; Ginzburg, A; Ullmann, Y; Paus, R; Gilhar, A

Xenografts of scalp skin from patients with androgenetic alopecia (AGA) on immunocompromised mice provide an excellent preclinical research system for testing candidate AGA therapeutics under clinically relevant conditions in vivo.1 Therefore, we asked in a further refined version of this humanized AGA mouse model whether autologous platelet-rich plasma (PRP), which has been used increasingly for AGA management,2 significantly impacts on the two aspects of AGA that are critical for the therapeutic outcome: a) the telogen:anagen ratio; and b) reconversion of the vellus into terminal scalp hair follicles (HFs).3.