Preparation, characterization and antioxidant determination of coumarin substituted heterocyclic compound

Abd-Almonuim, A. E.; Mohammed, S. M.; Al-Khalifa, I. I.

The recent work involves the preparation and characterization of 3-(4-hydroxy-4H-benzo [4, 5] thiazolo [3, 2-a] pyrimidin-4-yl)-2H-chromen-2-one derivative in dioxin-ethanol medium. The enamine (E)-1, 1-dimethyl-3-((2-oxo-2H-chromen-3-yl) methylene) urea was treated in dioxin solvent with ethanolic solution of 2-aminobenzothiazole to produce named 3-(4-hydroxy-4H-benzo[4, 5]thiazolo[3, 2-a]pyrimidin-4-yl)-2H-chromen-2-one compound [L]. The prepared derivatives, enamine [A] and [L] were characterized through (C.H.N.S) analyses, FT-IR, 1HNMR as well Mass spectral. The scavenging ability from different ethanolic solution ranging from (100-1000 ug/ml) of the new compound against stable DPPH radical (DPPH) was done and the results show that the coumarin derivative of this compound exhibited high antioxidant activates with scavenging activity reaching 80% at concentration 1000 micro g/mL, compared to vitamin c as standard antioxidant reaching 92% DPPH radical scavenging activity at the same concentration.