Selected article for: "host translation and protein synthesis"
Author: Han Suh Kang; Katelyn McNair; Daniel A. Cuevas; Barbara A. Bailey; Anca M. Segall; Robert A. Edwards
Title: Prophage genomics reveals patterns in phage genome organization and replication
  • Document date: 2017_3_7
    • ID: 0abutzb3_37
    Snippet: A set of 17,539 tRNA genes were identified from the phages in our total dataset and condensed to a subset of 3,833 tRNA genes (as described for the integrase genes). As expected, the tRNA gene profiles in the phages reflect the number of synonymous codons for each tRNA (Fig. 6) . However, we found that tRNA-Met is one of the most commonly carried tRNA genes among the prophages we studied. Phages often encode a peptide deformylase enzyme that remo.....
    Document: A set of 17,539 tRNA genes were identified from the phages in our total dataset and condensed to a subset of 3,833 tRNA genes (as described for the integrase genes). As expected, the tRNA gene profiles in the phages reflect the number of synonymous codons for each tRNA (Fig. 6) . However, we found that tRNA-Met is one of the most commonly carried tRNA genes among the prophages we studied. Phages often encode a peptide deformylase enzyme that removes the formyl group from newly synthesized proteins (53, 54) . We propose that the methionine tRNA genes encoded by the prophages are included to increase the overall rate of translation when the phage enters the lytic cycle. Together, the peptide deformylase and tRNA-Met suggest that phage protein synthesis saturates the host's protein synthesis machinery and that, in many cases, optimal production of phage progeny requires protein translation capacity which exceeds that provided by the host.

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