Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_115
Snippet: 14 Results Version 1 (March 25-March 31, 2020) Version 1 was designed as proof of concept rapid prototype to capture essential (but highly simplified) elements of viral endocytosis, protein synthesis, viral assembly, release, and diffusion to infect other cells. The model was tailored to RNA viruses on a tissue monolayer (modeled as a layer of epithelium over a basement membrane). This version was kept deliberately simple to create an early start.....
Document: 14 Results Version 1 (March 25-March 31, 2020) Version 1 was designed as proof of concept rapid prototype to capture essential (but highly simplified) elements of viral endocytosis, protein synthesis, viral assembly, release, and diffusion to infect other cells. The model was tailored to RNA viruses on a tissue monolayer (modeled as a layer of epithelium over a basement membrane). This version was kept deliberately simple to create an early starting framework to help coalesce community feedback and contributions. It was also designed to test the use of interactive cloud-hosted models to help accelerate feedback by virologists and other domain experts through live demos.
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