Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_157
Snippet: We next decreased the cell tolerance to viral load by decreasing the pharmacodynamic half max AH from 500 virions to 10, while leaving frelease = 1. As expected, cell death and tissue damage occurred much more quickly under these parameters. Interestingly (and contrary to intuition), this did not significantly alter the rate at which the infection spread through the tissue. Compare the final frame of row C (higher tolerance to viral load) to row .....
Document: We next decreased the cell tolerance to viral load by decreasing the pharmacodynamic half max AH from 500 virions to 10, while leaving frelease = 1. As expected, cell death and tissue damage occurred much more quickly under these parameters. Interestingly (and contrary to intuition), this did not significantly alter the rate at which the infection spread through the tissue. Compare the final frame of row C (higher tolerance to viral load) to row D (lower tolerance to viral load) in Figure 3 . This shows the importance of creating spatiotemporal models of viral replication in tissues, as the balance of competing processes can lead to unexpected dynamics at the tissue, organ, and organism levels.
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