Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_92
Snippet: The design principles of the CIABM are: 1) CD8-dynamics focused detail, 2) incorporation of the IIRABM as the innate-host tissue module, 3) incorporation of humoral and CD4 T-cell function, but at an abstracted level.The justification for aggregating humoral and CD4 functions is that they are primarily governed by interactions through the MHC2 complex, and therefore represent a distinct sensing/recognition capacity than CD8.....
Document: The design principles of the CIABM are: 1) CD8-dynamics focused detail, 2) incorporation of the IIRABM as the innate-host tissue module, 3) incorporation of humoral and CD4 T-cell function, but at an abstracted level.The justification for aggregating humoral and CD4 functions is that they are primarily governed by interactions through the MHC2 complex, and therefore represent a distinct sensing/recognition capacity than CD8
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