Author: Satchidanandam, V.; Pradeep, S. P.; Venkatesh, P. H.; Manchala, N. R.; Veedu, A. V.; Basavaraju, R. K.; Selvasundari, L.; Ramakrishna, M.; Chandrakiran, Y.; Krishnamurthy, V.; Holigi, S.; Thomas, T.; Ross, C. R.; Dias, M.
Title: Innate immune cytokine profiling and biomarker identification for outcome in dengue patients Cord-id: pv7tgwcg Document date: 2020_10_15
ID: pv7tgwcg
Snippet: Biomarkers of progression to severe dengue are urgently required for effective patient management. Innate immune cells have been implicated in the enhancement of infection and cytokine storm associated with dengue severity. Using intracellular cytokine staining and flow cytometry, we observed significantly higher proportions of innate immune cells secreting inflammatory cytokines dominated by IFN-{gamma} and TNF- at admission associated with good prognosis. Secondary dengue predisposed to severe
Document: Biomarkers of progression to severe dengue are urgently required for effective patient management. Innate immune cells have been implicated in the enhancement of infection and cytokine storm associated with dengue severity. Using intracellular cytokine staining and flow cytometry, we observed significantly higher proportions of innate immune cells secreting inflammatory cytokines dominated by IFN-{gamma} and TNF- at admission associated with good prognosis. Secondary dengue predisposed to severe outcomes. In patients with severe dengue and those with liver impairment, early activation as well as efficient down-regulation of innate responses were compromised. IFN-{gamma}+CD56+CD3+ NKT cells and IL-6+ granulocytes served as novel biomarkers of progression to severity (composite AUC=0.85-0.9). Strong correlations among multiple cytokine-secreting innate cell subsets pointed to coordinated activation of the entire innate immune system by DENV.
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