Author: Cunningham, Janet L; Virhammar, Johan; Rönnberg, Bengt; Castro Dopico, Xaquin; Kolstad, Linda; Albinsson, Bo; Kumlien, Eva; Nääs, Anja; Klang, Andrea; Westman, Gabriel; Zetterberg, Henrik; Frithiof, Robert; Lundkvist, Åke; Karlsson Hedestam, Gunilla B; Rostami, Elham
Title: Anti-SARS-CoV2 antibody responses in serum and cerebrospinal fluid of COVID-19 patients with neurological symptoms Cord-id: tqil35of Document date: 2021_3_21
ID: tqil35of
Snippet: Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF an
Document: Antibody responses to SARS-CoV-2 in serum and CSF from 16 COVID-19 patients with neurological symptoms were assessed using two independent methods. IgG specific for the virus spike protein was found in 81% of cases in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in two cases with negative serology. Levels of IgG in both serum and CSF were associated with disease severity (p<0.05). All patients with elevated markers of CNS damage in CSF also had CSF antibodies (p=0.002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
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