Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_15
Snippet: For creating a more specific antibody directed against SARS-CoV-2 spike RBD, we replaced residues of the CDR regions of the m396 crystallized FAB portion with residues that may complement and fulfill better the SARS-CoV-2 RBD surface. Mutagenesis analyses and modeling of the incomplete residues within the crystallized structures were performed by using SPDBV (46) and/or PyMOL (47)......
Document: For creating a more specific antibody directed against SARS-CoV-2 spike RBD, we replaced residues of the CDR regions of the m396 crystallized FAB portion with residues that may complement and fulfill better the SARS-CoV-2 RBD surface. Mutagenesis analyses and modeling of the incomplete residues within the crystallized structures were performed by using SPDBV (46) and/or PyMOL (47).
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