Author: Haoyan Chen; Baoqin Xuan; Yuqing Yan; Xiaoqiang Zhu; Chaoqin Shen; Gang Zhao; Linhua Ji; Danhua Xu; Hua Xiong; TaChung Yu; Xiaobo Li; Qiang Liu; Yingxuan Chen; Yun Cui; Jie Hong; Jing-Yuan Fang
Title: Profiling ACE2 expression in colon tissue of healthy adults and colorectal cancer patients by single-cell transcriptome analysis Document date: 2020_2_23
ID: 3r0nqzgu_5
Snippet: To investigate the ACE2 expression pattern in the gastrointestinal tract of Asian adult samples, we incorporated two public single cell RNA-seq data of colorectal cancer (CRC) cohorts from GEO (GSE97693 and GSE81861) and one cohort from Renji Hospital. We performed single cell analysis on 504 cells from GSE97693, including 485 cell from CRC (primary tumor) and 19 cells from healthy normal control (NC). We observed that ACE2 is expressed in 38.5%(.....
Document: To investigate the ACE2 expression pattern in the gastrointestinal tract of Asian adult samples, we incorporated two public single cell RNA-seq data of colorectal cancer (CRC) cohorts from GEO (GSE97693 and GSE81861) and one cohort from Renji Hospital. We performed single cell analysis on 504 cells from GSE97693, including 485 cell from CRC (primary tumor) and 19 cells from healthy normal control (NC). We observed that ACE2 is expressed in 38.5%(194/504) of all human colon cells. We also observed that the ACE2 expressed cells were significantly enriched in tumors when compared with healthy normal tissues (39.6% vs 10.5%, p <0.05) ( Fig. 1 A-C) .
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