Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_75
Snippet: The viral genomic copy numbers inside the cells will also be assessed by qRT-PCR and compared to the genomic copies outside the cell. This will provide direction on the efficacy of particle packaging and the extent of production of infectious versus noninfectious virus. While it will not provide directly pertinent information about the possibility of heterogeneity of released virus populations and quasispecies, it can provide initial clues in tha.....
Document: The viral genomic copy numbers inside the cells will also be assessed by qRT-PCR and compared to the genomic copies outside the cell. This will provide direction on the efficacy of particle packaging and the extent of production of infectious versus noninfectious virus. While it will not provide directly pertinent information about the possibility of heterogeneity of released virus populations and quasispecies, it can provide initial clues in that direction, which can then trigger more specific questions and relevant approaches. These approaches will be pursued for cell lines, primary cells and, hopefully, subsequently transitioned to organoid platforms.
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