Author: Piguet, Vincent; Steinman, Ralph M.
Title: The interaction of HIV with dendritic cells: outcomes and pathways Cord-id: r7b0o03f Document date: 2007_10_23
ID: r7b0o03f
Snippet: Dendritic cells (DCs), including Langerhans Cells (LCs), are probably among the earliest targets of HIV infection. Their localization in mucosal epithelia and in the T cell areas of lymphoid organs, as well as their crucial role in capturing antigens and initiating T cell responses, highlight their potential importance. Studies with cells in culture have addressed different outcomes of the HIV-–DC interaction, which include: direct productive infection of DC; carriage of virus by DC to CD4(+)
Document: Dendritic cells (DCs), including Langerhans Cells (LCs), are probably among the earliest targets of HIV infection. Their localization in mucosal epithelia and in the T cell areas of lymphoid organs, as well as their crucial role in capturing antigens and initiating T cell responses, highlight their potential importance. Studies with cells in culture have addressed different outcomes of the HIV-–DC interaction, which include: direct productive infection of DC; carriage of virus by DC to CD4(+) T cells; transfer of virus between DC and T cells at an infectious synapse; and immune evasion strategies of infected DC. Here we review the literature covering these areas, including current knowledge of underlying mechanisms or pathways.
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