Author: Bo Shen; Xiao Yi; Yaoting Sun; Xiaojie Bi; Juping Du; Chao Zhang; Sheng Quan; Fangfei Zhang; Rui Sun; Liujia Qian; Weigang Ge; Wei Liu; Shuang Liang; Hao Chen; Ying Zhang; Jun Li; Jiaqin Xu; Zebao He; Baofu Chen; Jing Wang; Haixi Yan; Yufen Zheng; Donglian Wang; Jiansheng Zhu; Ziqing Kong; Zhouyang Kang; Xiao Liang; Xuan Ding; Guan Ruan; Nan Xiang; Xue Cai; Huanhuan Gao; Lu Li; Sainan Li; Qi Xiao; Tian Lu; Yi Judy Zhu; Huafen Liu; Haixiao Chen; Tiannan Guo
Title: Proteomic and Metabolomic Characterization of COVID-19 Patient Sera Document date: 2020_4_7
ID: nifz133q_6
Snippet: Suppressed platelet degranulation in severe sera 220 Fifteen of 17 proteins involved in platelet degranulation were down-221 regulated in SARS-CoV-2 infected patients, which may be associated with 222 observed thrombocytopenia in this patient cohort (Zheng et al., 2020) . Low 223 platelet count is also reported to be associated with severe COVID-19 and 2.07-fold (p = 1.86e-04) and 3.31-fold (p = 9.07e-07), respectively. 240 We also detected low l.....
Document: Suppressed platelet degranulation in severe sera 220 Fifteen of 17 proteins involved in platelet degranulation were down-221 regulated in SARS-CoV-2 infected patients, which may be associated with 222 observed thrombocytopenia in this patient cohort (Zheng et al., 2020) . Low 223 platelet count is also reported to be associated with severe COVID-19 and 2.07-fold (p = 1.86e-04) and 3.31-fold (p = 9.07e-07), respectively. 240 We also detected low levels of fatty acids such as arachidonate and the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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