Author: MS Zinter; CC Dvorak; MY Mayday; K Iwanaga; NP Ly; ME McGarry; GD Church; LE Faricy; CM Rowan; JR Hume; ME Steiner; ED Crawford; C Langelier; K Kalantar; ED Chow; S Miller; K Shimano; A Melton; GA Yanik; A Sapru; JL DeRisi
Title: Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children Document date: 2018_3_29
ID: 28nlawnb_1
Snippet: Last year in the United States, approximately 15,000 children were diagnosed with cancer, 2,000 children underwent solid organ transplantation (SOT), and 2,500 children underwent hematopoietic cell transplantation (HCT) for an increasingly broad set of life-threatening diseases (1) (2) (3) . While significant progress has been made in improving the safety of anti-neoplastic and transplantation-based therapies, the risk of infectious complications.....
Document: Last year in the United States, approximately 15,000 children were diagnosed with cancer, 2,000 children underwent solid organ transplantation (SOT), and 2,500 children underwent hematopoietic cell transplantation (HCT) for an increasingly broad set of life-threatening diseases (1) (2) (3) . While significant progress has been made in improving the safety of anti-neoplastic and transplantation-based therapies, the risk of infectious complications remains high (4) . In particular, lower respiratory tract infections in children who have undergone HCT are associated with mortality rates exceeding 45% (5, 6) . Current microbiologic diagnostics are inadequate and fail to identify a pathogenic organism in over one third of such cases (7) .
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