Author: Ahmed, Rafi; Oldstone, Michael B A; Palese, Peter
                    Title: Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic  Cord-id: uibes3jl  Document date: 2007_10_19
                    ID: uibes3jl
                    
                    Snippet: The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documen
                    
                    
                    
                     
                    
                    
                    
                    
                        
                            
                                Document: The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.
 
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