Selected article for: "particle assembly and virus particle"
Author: Bruna GG Pinto; Antonio ER Oliveira; Youvika Singh; Leandro Jimenez; Andre NA Goncalves; Rodrigo LT Ogava; Rachel Creighton; Jean PS Peron; Helder I Nakaya
Title: ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19
  • Document date: 2020_3_27
    • ID: 2un9aggj_36
    Snippet: The "viral life cycle" pathway that was enriched with up-regulated genes in patients with severe COVID-19 comorbidities contains several genes other than ACE2 that can be potentially important for SARS-CoV-2 cell cycle and invasion/attachment. These include RAB1A gene, whose product promotes the replication of Vaccinia virus [38] . Also, RAB1A is important for Herpes Simplex Virus 1 Secondary Envelopment [39] , and is required for assembly of cla.....
    Document: The "viral life cycle" pathway that was enriched with up-regulated genes in patients with severe COVID-19 comorbidities contains several genes other than ACE2 that can be potentially important for SARS-CoV-2 cell cycle and invasion/attachment. These include RAB1A gene, whose product promotes the replication of Vaccinia virus [38] . Also, RAB1A is important for Herpes Simplex Virus 1 Secondary Envelopment [39] , and is required for assembly of classical swine fever virus particle [40] . It is possible that SARS-CoV-2 utilizes RAB1A as well.

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