Selected article for: "clinical variation and large population"
Author: Toubiana, Julie; Courtine, Emilie; Tores, Frederic; Asfar, Pierre; Daubin, Cédric; Rousseau, Christophe; Ouaaz, Fatah; Marin, Nathalie; Cariou, Alain; Chiche, Jean-Daniel; Mira, Jean-Paul
Title: Association of REL polymorphisms and outcome of patients with septic shock
  • Cord-id: u6dfp6gf
  • Document date: 2016_4_8
    • ID: u6dfp6gf
    Snippet: BACKGROUND: cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown. METHODS: We genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of
    Document: BACKGROUND: cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown. METHODS: We genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of REL; REL rs842647 and REL rs13031237. Outcome of patients according to the presence of REL variant alleles was compared. RESULTS: The distribution of REL variant alleles was not significantly different between patients and controls. Among the septic shock group, REL rs13031237*T minor allele was not associated with worse outcome. In contrast, REL rs842647*G minor allele was significantly associated with more multi-organ failure and early death [OR 1.4; 95 % CI (1.02–1.8)]. CONCLUSION: In a large ICU population, we report a significant clinical association between a variation in the human REL gene and severity and mortality of septic shock, suggesting for the first time a new insight into the role of cRel in response to infection in humans.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
    • acute ards respiratory distress syndrome and adequate fluid resuscitation: 1, 2
    • acute ards respiratory distress syndrome and adhesion molecule: 1, 2, 3, 4, 5, 6
    • acute ards respiratory distress syndrome and adjuvant treatment: 1, 2, 3, 4
    • acute ards respiratory distress syndrome and liver insufficiency: 1, 2
    • acute ards respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
    • acute ards respiratory distress syndrome and logistic regression model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • acute ards respiratory distress syndrome and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • adaptive immunity and adjuvant treatment: 1, 2, 3, 4, 5
    • adaptive immunity and logistic regression: 1, 2, 3, 4
    • adaptive immunity and lymphocyte proliferation: 1, 2
    • adaptive immunity and macrophage activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • adhesion molecule and liver insufficiency: 1
    • adhesion molecule and logistic regression: 1, 2, 3, 4, 5
    • adhesion molecule and macrophage activation: 1
    • adjuvant treatment and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8
    • adjuvant treatment and logistic regression model: 1
    • liver insufficiency and logistic regression: 1, 2
    • logistic regression and macrophage activation: 1, 2, 3, 4